MolWard unifies a dozen validated in-silico engines with a citation-grounded regulatory assistant — one always-warm platform spanning discovery, CMC and submission. Forced-degradation, ICH M7 toxicology, ICH Q1E stability, ICH Q3 impurity limits, dissolution f2 equivalence, chromatography & column selectivity, QbD design-of-experiments, ICH Q14 method development, USP/ICH QC calculators, dose- and exposure-limit calculators, and RegIntel regulatory search — built on transparent chemistry and zero data retention.
Engineered for global regulatory compliance
Traditional development relies on expensive, late-stage empirical testing. Unforeseen liabilities — a mutagenic impurity, an oxidative degradant, a shelf-life that fails at month 12 — can trigger clinical holds and cost millions. MolWard shifts risk assessment to the earliest stages of design, with rigorous, transparent chemistry.
Read the science behind MolWard"Cohort of Concern" impurities now carry intake limits as low as 18 ng/day.
An out-of-trend assay pull at month 12 can derail an IND timeline and trigger OOS investigations.
Mutagenic toxicophores discovered in the lab cost millions to remediate.
Four capability areas, one defensible pipeline: analytical & CMC development (stability, impurity limits, dissolution, chromatography & column selectivity, QbD DoE, ICH Q14, QC calculators), degradation & toxicology, safety & exposure limits (HED/MRSD, PDE/ADE/OEL), and regulatory intelligence — all built on transparent, published chemistry.
Computationally simulate hydrolytic, oxidative, photolytic, and thermal stress. Map complete degradation pathways and generate MS fragmentation profiles to accelerate SIM development.
Execute a compliant dual-methodology (Expert Rule + Statistical QSAR) hazard assessment. Automatically calculate FDA CPCA nitrosamine scores, acceptable intake limits, and extract empirical read-across data.
Two modes: statistically evaluate long-term data per ICH Q1E (95% LCB shelf-life, OOT flagging), or predict shelf-life from accelerated stress data with a moisture-modified Arrhenius fit. Every run generates a signed-off-ready PDF report.
Enter a single maximum daily dose and route to instantly generate all applicable ICH Q3 thresholds — organic impurities, residual solvents, elemental impurities, and extractables AET.
Compare two dissolution profiles the way a regulator does: the f2 similarity and f1 difference factors, the 85% rule and RSD eligibility checks, and a bootstrap 90% CI of f2 for high-variability products.
Predict reversed-phase chromatograms and elution order from SMILES, scout columns / mobile phases / pH, and get a recommended detection wavelength — straight from a degradation run or a custom molecule list.
Compare reversed-phase HPLC columns objectively with the published Hydrophobic-Subtraction Model — rank equivalents and flag non-interchangeable columns before you re-validate a method.
Design an experiment, fit a response-surface model, and map the ICH Q8(R2) design space — the multivariate region where every response stays in specification — with a Monte-Carlo edge of failure. The QbD workflow scientists return to for every formulation, process or method they optimize.
Define an Analytical Target Profile, run a formal FMEA (RPN = S × O × D) with in-silico auto-scoring from method physics, screen robustness against the Method Operable Design Region (MODR), and generate a SHA-256-stamped, AI-interpreted risk-control report — the ICH Q14 analytical-procedure workflow, free in the browser.
The everyday QC-lab calculations, done right and free in the browser — system suitability, buffer recipes, LOD/LOQ, content uniformity and outlier tests. Five compendial calculators in one place, no upload, computed locally.
Convert an animal dose to the Human Equivalent Dose by body-surface-area Km ratio and derive the Maximum Recommended Starting Dose for a first-in-human trial.
Derive the Permitted / Acceptable Daily Exposure, Occupational Exposure Limit and OEB band from a NOAEL — for cleaning validation, shared facilities and worker safety.
RegIntel answers your ICH, 21 CFR and FDA questions from the source documents themselves — and shows the verbatim passage and reference behind every answer. No hallucinated citations, no guessing: if the corpus doesn't cover it, it says so.
Grounded in ICH guidelines, 21 CFR, FDA guidances, warning letters and annual reports.
Every answer quotes the exact source passage — with a link to the document.
If the corpus doesn't contain the answer, RegIntel says so — it never fabricates.
Every result traces to a published ICH/USP/FDA method; every report carries a SHA-256 integrity stamp and the platform version; and every AI draft is numerically fenced, citation-restricted, and labelled for expert review. Your structures are never stored — computation is zero-retention.
Every prediction is verified against the chemical space of the training data.
Feature attributions explain the structural drivers behind each result.
AI drafts read only computed facts and cite only allow-listed ICH guidelines — flagged for expert sign-off.
Anticipate chromatographic peaks and source USP/EP reference standards during SIM development.
Project shelf-life and investigate out-of-trend pulls with ICH Q1E statistics and an audit-ready report.
Generate rapid, defensible dual-methodology risk assessments for submissions.
Identify synthesis-route risks, particularly nitrosating agents and amine precursors.
Scout chromatography columns and mobile phases, and compare dissolution profiles by f2 for scale-up and biowaivers.
How the FDA body-surface-area Km ratio converts an animal dose to the Human Equivalent Dose, and how the safety factor turns it into a defensible Maximum Recommended Starting Dose for a first-in-human trial.
Read the article → Toxicology & SafetyHow Random Forest algorithms reason over chemical topology, and why 2048-bit Morgan fingerprints trained on curated Hansen/ECVAM datasets beat legacy methods on ROC-AUC.
Read the article → Toxicology & SafetyWhy deep-learning models fail regulatory scrutiny without mechanistic explanations — and how ICH M7's dual expert-rule-plus-statistical architecture keeps AI-assisted toxicology defensible.
Read the article →Beyond the open platform, MolWard runs access-controlled engines for specialised workflows — provisioned to qualified teams on request.
Full ICH Q2(R2) validation statistics — accuracy, precision & intermediate precision, linearity/range, LOD/LOQ, specificity — across quantitative, non-linear (4PL), limit and qualitative method types, with an audit-ready report.
Ranks equivalent chromatography resins for a bioprocess resin change from the protein's own biophysics — capture performance and same-ligand-family alternatives, to narrow the shortlist before wet-lab DBC work.
Run your first in silico assessment free and see the regulatory-grade output for yourself.